We have explored the application of new supramolecular probes combining with nano-scaled materials in biomolecular recognition and highly-sensitive detection of diseases, such as cancer. We have found that selfassembly of the specific nanocomposites with the new molecular probes could provide a multifunctional interface for the highly sensitive intracellular redox sensing and rapid identification of diseased cells including cancer cells, with a broad detection range and low detection limit. Moreover, we have also developed ultrasensitive and smart multi-functional nanoprobes based on the in vivo biosynthesized nanoclusters for multimodality imaging of cancers and many other diseases.
Dr. Xuemei Wang is a Full Professor in Southeast University, Nanjing, China. She got her PhD degree in Chemistry from Nanjing University in 1995. Since 1998, she has been a professor in School of Biological Science and Medical Engineering, Southeast University. In 2000, she was awarded Hong Kong Croucher Research Fund and The Youth Prize in Chemistry by the Chinese Chemical Society. She was also elected into the New Century Excellent Talents Support Program in China in 2005 and won Chinese Young Women Scientists’ Award in 2007. In 2013, she won The National Science Fund for Distinguished Young Scholars in China. She has published more than 100 papers in international journals including Angewandte Chemie International Edition, Adv. Funct. Mater., Biomaterials, etc. Her current research interests include biomaterials and biosensors, nanomedicine, and multimode bioimaging, especially focused on the in vivo biolabelling of tumors and other related disease through the combination of the in-situ biosynthesized biocompatible multifunctional metal nano-clusters and relevant nanoscale probes.